Publications

Unleashing the potential of mRNA-seq to uncover the microbiome structure and their crosstalk with host cells: the vulvar ecosystem

Background To describe both host gene expression and microbiome composition in a single sample, …

Tissue Memory Relies on Stem Cell Priming in Distal Undamaged Areas

20 April 2023

Epithelial cells that participated in wound repair elicit a more efficient response to future …

Molecular mechanisms and therapeutic perspectives in vulvodynia: From current evidence to future investigations

Vulvodynia is defined as chronic vulvar pain persisting for at least 3 months without a clear …

DNMT3B supports meso-endoderm differentiation from mouse embryonic stem cells

23 January 2023

The correct establishment of DNA methylation patterns during mouse early development is essential …

3plex enables deep computational investigation of triplex forming lncRNAs

2023

Long non-coding RNAs (lncRNAs) regulate gene expression through different molecular mechanisms, …

Single-Cell Sequencing for Everybody

07 December 2021

Over the past 7 years, single-cell sequencing has become very popular. For this reason, many …

Flow Cytometry for Beginners: Hints and Tips for Approaching the Very First Single-Cell Technique

2021

While many single-cell proteomics techniques have been rapidly developed over the past decade, flow …

Hair follicle stem cell progeny heal blisters while pausing skin development

4 June 2021

Injury in adult tissue generally reactivates developmental programs to foster regeneration, but it …

Long Noncoding RNAs in Human Stemness and Differentiation

March 01, 2021

Embryonic differentiation at the gastrulation stage is a very tightly regulated process in …

The Lysine Methylase SMYD3 Modulates Mesendodermal Commitment during Development

18 May 2021

SMYD3 (SET and MYND domain containing protein 3) is a methylase over-expressed in cancer cells and …

Mapping Rora expression in resting and activated CD4+ T cells

2021

The transcription factor Rora has been shown to be important for the development of ILC2 and the …

Gene expression variability across cells and species shapes innate immunity

24 October 2018

As the first line of defence against pathogens, cells mount an innate immune response, which varies …

Locked and Loaded: Inflammation Training Prepares Skin Epithelial Stem Cells for Trauma

7 December 2017

Memory of a trauma and how to cope with it is useful for acting rapidly in the event of a second …

Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation

2016

Background Differentiation of lymphocytes is frequently accompanied by cell cycle changes, …

T cell fate and clonality inference from single-cell transcriptomes

2016

We developed TraCeR, a computational method to reconstruct full-length, paired T cell receptor (TCR) …

Flow Cytometry for Beginners: Hints and Tips for Approaching the Very First Single-Cell Technique

12 November 2021

While many single-cell proteomics techniques have been rapidly developed over the past decade, flow …

Single‐cell technologies are revolutionizing the approach to rare cells

2015

In the last lustrum single-cell techniques such as single-cell quantitative PCR, RNA and DNA …

Single‐cell technologies to study the immune system

2015

The immune system is composed of a variety of cells that act in a coordinated fashion to protect the …

Computational assignment of cell-cycle stage from single-cell transcriptome data

2015

The transcriptome of single cells can reveal important information about cellular states and …

Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells

2015

Recent technical developments have enabled the transcriptomes of hundreds of cells to be assayed in …

Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis

2014

T helper 2 (Th2) cells regulate helminth infections, allergic disorders, tumor immunity, and …

Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors

It has long been recognized that the hair follicle growth cycle and oscillation in the thickness of …

Accounting for technical noise in single-cell RNA-seq experiments

2013

Single-cell RNA-seq can yield valuable insights about the variability within a population of …

The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy

2013

Elucidating the epigenetic mechanisms underlying muscle mass determination and skeletal muscle …

TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration

2010

How regeneration cues are converted into the epige- netic information that controls gene expression …